12/3/2023 0 Comments Scn1a dendrite axon![]() Moreover, we discuss how the contribution of dendrites and axons to neuronal excitability may impose constraints on the morphology of these compartments in specific functional contexts. In this article, we present a few examples of “misbehaving” neurons (with a non-canonical polarity scheme) to highlight the diversity of solutions that are used by mammalian neurons to transmit information. In several interneuron types, all functions are carried out by dendrites as these neurons are devoid of a canonical axon. In fact, dendrites can be the site of AP initiation and propagation, and even neurotransmitter release. Even though this canonical division of labor is true for a number of neuronal types in the mammalian brain (including neocortical and hippocampal pyramidal neurons or cerebellar Purkinje neurons), many neuronal types do not comply with this classical polarity scheme. All rights reserved.Our general understanding of neuronal function is that dendrites receive information that is transmitted to the axon, where action potentials (APs) are initiated and propagated to eventually trigger neurotransmitter release at synaptic terminals. Thus, axon-carrying dendrites constitute a privileged channel for excitatory synaptic input in a subset of cortical pyramidal cells.Ĭopyright © 2014 Elsevier Inc. Second, AcDs are intrinsically more excitable, generating dendritic spikes with higher probability and greater strength. First, synaptic input onto AcDs generates action potentials with lower activation thresholds compared with regular dendrites. Multiphoton glutamate uncaging revealed that input onto the axon-carrying dendrites (AcDs) was more efficient in eliciting action potential output than input onto regular basal dendrites. This morphology is particularly enriched in central CA1, the principal hippocampal output area. However, we found that axons of hippocampal pyramidal cells frequently derive from a basal dendrite rather than from the soma. The axon initial segment, the proposed site of action potential generation, usually emanates directly from the soma. Electronic address: processing is classically conceptualized as dendritic input, somatic integration, and axonal output. 6 Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany Bernstein Center for Computational Neuroscience (BCCN) Heidelberg/Mannheim, 69120 Heidelberg, Germany.5 Institute for Anatomy and Cell Biology, Heidelberg University, 69120 Heidelberg, Germany.4 Institute of Neuroanatomy, Center for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany. ![]() 3 Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany.2 Laboratory for Cognition Research and Experimental Epileptology, Department of Epileptology, University of Bonn, 53127 Bonn, Germany.1 Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany Bernstein Center for Computational Neuroscience (BCCN) Heidelberg/Mannheim, 69120 Heidelberg, Germany. ![]()
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